DAY 1 : BREAKING DOWN THE BARRIERS Primary Target Audience: Patients and Caregivers
Symposium Day 1 Opening Welcome Introduction to CCRAN Welcome from CCRAN's President Calls to action from June 2021 Symposium Objectives for this year's EAOCRC Symposium	Monika Slovinec D'Angelo, Ph.D. Symposium Moderator Ms. Filomena Servidio-Italiano, OCT, M.A. President & CEO, CCRAN
Key Learnings from CCRAN's June 2021 Symposium Lead authors of two papers produced from CCRAN's 2021 EAOCRC Symposium will speak to key findings that highlight the importance of early colorectal cancer screening, particularly in young adults whose symptoms may present differently. Speakers will also elaborate on progress, in terms of new evidence in support of earlier screening, over the past year.	Presentation Mary A. De Vera, Ph.D. Epidemiologist, Collaboration for Outcomes Research & Evaluation Research Scientist, University of British Columbia Darren Brenner Ph.D. Molecular Cancer Epidemiologist and Data Scientist, Armstrong Investigator in Molecular Epidemiology, University of Calgary
Panel Session 1: Breaking Down the Barriers to Timely Detection of Colorectal Cancer This session will address the question "Why are early symptoms too often dismissed by patients and care providers?" to: Facilitate an understanding of the EAOCRC care trajectory from different perspectives and shed light on issues that stand in the way of timely diagnosis of the pathology in younger patients. Examine perceptions (including barriers) at a population and health system level regarding CRC screening and testing that need to be addressed to help improve timely detection of EAOCRC. Explore opportunities for promoting awareness and education around the rising rates of EAOCRC in Canada, and inform strategies for improving timely diagnosis.	Moderator Monika Slovinec D'Angelo, Ph.D. Health Scientist, VBHC Research Lead Panel Ms. Stephanie Florian Widow of CRC patient, British Columbia Dr. Dan Schiller Colorectal Surgical Oncologist, University of Alberta Ms. Julie Savard Endoscopy Nurse Clinician, ERAS Coordinator, Jewish General Hospital Dr. Lisa Del Giudice Family Physician, Sunnybrook Academic Family Health Team, Sunnybrook Health Sciences Centre, Regional Primary Care Lead, Toronto Central, Ontario Health-Cancer Care Ontario
Health Break	Monika Slovinec D'Angelo, Ph.D. Health Scientist, VBHC Research Lead
Panel Session 2: Identifying and Addressing the Needs of Younger CRC Patients Younger patients (i.e., under age 50) are at a different stage in life and have different concerns and needs related to their CRC journey. This session will address challenges relevant to younger patients to highlight the importance of a multidisciplinary care approach. Panelists will address the young adult colorectal cancer patient's: Overall wellbeing and quality of life Support systems, resources and education opportunities for patients and family members Intimacy, sexuality, fertility preservation (i.e., sperm/egg banking) Disease management and treatment options	Moderator Dr. Petra Wildgoose Lead, Young Adult Colorectal Cancer Program, Sunnybrook Health Sciences Centre Panel Mr. Marcelino Dolores R.N. Patient Expert Dr. Mary Jane Esplen Psychosocial Oncologist. Department of Psychiatry, Faculty of Medicine, University of Toronto Dr. Michael Raphael GI Medical Oncologist, Odette Cancer Center at Sunnybrook Health Sciences Center Dr. David Gurau Obstetrician and Reproductive Endocrinologist, Generation Fertility
Health Break Integrative Therapies to Address Treatment-Induced Toxicities (pre-recorded video)	Dr. Eric Marsden Naturopathic Doctor and Director of Marsden Centre for Excellence in Integrative Medicine
Panel Session 3: Promoting Timely Detection of CRC: What Can We Learn from the American Experience? The US CRC screening age was lowered to 45 years in 2018. Patient advocacy groups from the U.S and Canada will explore system enablers of early symptom recognition and screening to improve timely diagnosis of EAOCRC. Panelists will address: The impetus for lowering the screening age and the role of each stakeholder (patients, caregivers, health care providers, payers, policy makers) in achieving this policy change. Barriers and opportunities at the primary care and population level, including the importance of patient education. Expected and observed impacts of the policy change to date. Application of learnings from the US to the Canadian context, including other approaches for modifying cancer screening criteria to systemically improve timely detection in Canada.	Moderator Dr. Robin McGee Psychologist and Stage 4 Rectal Cancer Patient Panel Mr. Andrew Spiegel, Esq. Executive Director, Global Colon Cancer Association (US) Ms. Martha Raymond Executive Director, GI Cancers Alliance Inc. (US) Ms. Becky Selig Director of Patient Education and Research, Fight Colorectal Cancer (US) Mr. Jason Gisser Board Member, AYA Canada Ms. Dani Taylor Manager of Programs and Partnerships, Young Adult Cancer Canada (YACC) Ms. Teresa Norris Founder and President, HPV Global Action
Panel Session 4: Advancements in Colorectal Cancer Treatments Clinical experts will highlight innovative treatments that can aid in the management of early age colorectal cancer. Discussion will focus on: Comprehensive genomic profiling and precision medicines (e.g., KRAS G12C, PI3CKA, HER2, MSI-H disease). Circulating tumor DNA (ctDNA), particularly as it relates to different types of assays and settings (adjuvant, metastatic etc.), including use of ctDNA in post-surgical setting to detect minimal residual disease.	Moderator Dr. Scott Berry GI Medical Oncologist, Cancer Centre of Southeastern Ontario at the Kingston Health Sciences Centre Panel Dr. Chris Lieu GI Medical Oncologist, University of Colorado Cancer Center Dr. Kim Ma Medical Oncologist, Segal Cancer Centre at Jewish General Hospital Dr. Eric Chen GI Medical Oncologist, Princess Margaret Cancer Centre Mr. Steve Slack Stage IV Rectal Cancer Patient
Closing remarks for Day 1. Glance at Day 2. Thank You.	Ms. Filomena Servidio-Italiano, OCT, M.A. President & CEO, CCRAN

DAY 2: OPTIMIZING COLORECTAL CANCER CARE & OUTCOMES Primary Target Audience: Clinicians, Researchers, Policy Makers, Industry
Symposium Day 2 Opening Welcome Introduction to CCRAN Welcome from CCRAN's President Welcome Calls to action from June 2021 Symposium Objectives for this year's EAOCRC Symposium	Monika Slovinec D'Angelo, Ph.D. Symposium Moderator Ms. Filomena Servidio-Italiano, OCT, M.A. President & CEO, CCRAN
What Do We Know and What Have We Learned About EAOCRC: Outputs from the June 2021 Symposium Lead authors of two papers that came out of CCRAN's 2021 EAOCRC Symposium will highlight the key findings and elaborate on the importance of early CRC screening, particularly in young adults whose symptoms may present differently.	Presentation Mary A. De Vera, Ph.D. Epidemiologist, Collaboration for Outcomes Research & Evaluation Research Scientist, University of British Columbia Dr. Clarence Wong Gastroenterologist, University of Alberta
Panel Session 5: Improving the EAOCRC patient care pathway Speakers will focus on opportunities for systemic improvements to CRC diagnostic and treatment pathways to address the common concern of patients: "Why was I dismissed when I presented with symptoms consistent with colorectal cancer … sent away with a diagnosis of hemorrhoids ...". The sessions will: Draw on younger patients' experiences with the CRC care journey and insights from a healthcare providers to better understand the underlying issues standing in the way of timely CRC diagnosis in younger patients. Examine perceptions (including barriers) regarding screening and testing that need to be addressed at a population and system wide level to help improve timely detection of EAOCRC. Examine differences in care pathways for younger patients and opportunities for addressing the challenges they face in order to improve the overall patient experience and outcomes.	Moderator Monika Slovinec D'Angelo, Ph.D. Health Scientist, VBHC Research Lead Panel Ms. Hayley Painter, R.N. Young Adult mCRC Patient, Early Age Onset CRC Patient Programs Manager, CCRAN Mr. Bill McGinley Stage IV Colorectal Cancer Patient; Chair, CCRAN's Patient Advisory Council Dr. Dan Schiller Colorectal Surgical Oncologist, University of Alberta Ms. Julie Savard Endoscopy Nurse Clinician, ERAS Coordinator, Jewish General Hospital Dr. Anna Wilkinson Family Physician, The Ottawa Academic Family Health Team; Program Director, PGY-3 Family Practice-Oncology; Regional Cancer Primary Care Lead, Champlain Region
Health Break	Monika Slovinec D'Angelo, Ph.D. Health Scientist, VBHC Research Lead
Panel Session 6: Defining Value and Building System Capacity for Timely Detection of EAOCRC This session will bring together the perspective of different disciplines to examine the value of timely detection of CRC. Experts will: Speak to the challenges associated with delayed detection of EAOCRC and the value of timely diagnosis. Examine requirements (e.g., system enablers) for creating a healthcare infrastructure that could accommodate timely screening and detection. Explore the possible benefits and hindrances of earlier detection through different lenses.	Moderator Dr. Jill Tinmouth, MD, Ph.D. Lead Scientist, ColonCancerCheck Program, Sunnybrook Research Institute Panel Dr. Petra Wildgoose Family Physician and Lead, Young Adult Colorectal Cancer Program at Odette Cancer Centre, Sunnybrook Health Sciences Centre Dr. Yooj Ko Medical Oncologist Odette Cancer Centre, Sunnybrook Health Sciences Centre Ms. Eva Villalba, MBA, VBHC Greenbelt Value Based Health Care Expert and Executive Director, Quebec Cancer Coalition Jason Sutherland, Ph.D. Economist and Interim Director, Centre for Health Services and Policy Research Dr. Ian Bookman Gastroenterologist, St. Joseph's Health Centre Mr. Fred Horne Health Policy Consultant, Horne and Associates
Panel Session 7: Best Practices for Systematically Improving Management of EAOCRC The specific needs of young cancer patients are not being met, partly because their unique care and treatment needs are not recognized. This session will examine opportunities for optimizing care and treatment pathways in service of improving EAOCRC patient outcomes. Leads of existing young onset cancer programs in the US and Canada will share best practices that are being implemented in their respective clinics. The discussion will focus on: Unique needs of patients with early vs. late onset cancers. Need for specialized clinics and impetus for starting them. Challenges with launching programs and how they can be overcome. Importance of integrated care models delivered by multidisciplinary teams, and disciplines that need to be involved. Evidence-based best practices that improve disease management and outcomes of younger patients.	Moderator Dr. Sharlene Gill GI Medical Oncologist, BC Cancer Agency Panel Dr. Shady Ashamalla Surgical Oncologist, Odette Cancer Centre, Sunnybrook Health Sciences Centre Dr. Kimmie Ng GI Medical Oncologist, Dana-Farber Cancer Institute Dr. Robin Mendelsohn Gastroenterologist, Memorial Sloan Kettering Cancer Center Dr. Aparna Parikh GI Oncologist, Director, MGH Cancer Center's Global Cancer Care Program, Massachusetts General Hospital Cancer Center Dr. Cathy Eng GI Medical Oncologist, Vanderbilt-Ingram Cancer Centre
Health Break	Monika Slovinec D'Angelo, Ph.D. Health Scientist, VBHC Research Lead
Panel Session 8: Accessing Innovations in CRC Diagnostics and Treatment This session will offer insights on advancements in CRC diagnostics and treatments, including their access and utilization in Canada. Through an interactive dialogue, experts from Canada, US and Europe will examine: Advancements in CRC diagnostics (e.g., genomic profiling, biomarker testing) and treatments (e.g., precision medicine, circulating tumor DNA) and their application for young onset CRC patients. Opportunities for promoting awareness, education and application of innovations for improving treatment in stage 2 and 3 cancer patients and for increasing their eventual uptake and use in Canada. Opportunities for increasing uptake in Canada and promoting patient access to innovative diagnostics and treatments in the metastatic setting.	Moderator Dr. Michael Raphael GI Medical Oncologist, Sunnybrook Health Sciences Centre Panel Dr. Arvind Dasari Medical Oncologist, Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Centre Dr. Aaron Pollett Anatomic Pathologist, Division of Diagnostic Medical Genetics at Mount Sinai Hospital Dr. Stephanie Snow Medical Oncologist, QEII Health Sciences Centre Dr. Clarence Wong Gastroenterologist, University of Alberta Dr. Jose Perea Colorectal Surgeon, Surgery Department, Jimenez Diaz Foundation University Hospital, Madrid, Spain Mr. Bill McGinley Stage IV Colorectal Cancer Patient; Chair, CCRAN's Patient Advisory Council
Closing remarks for Day 2 and Symposium. Thank you.	Ms. Filomena Servidio-Italiano, OCT, M.A. President & CEO, CCRAN

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